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Chimie Physique et Chimie Analytique de Paris-Centre
ED388

Conférences en Chimie bio-inorganique

We are pleased to inform you that a series of conferences on bio-inorganic chemistry will be taking place in 2018 with the following program.

The conferences will be held at ENS in the room of the elements (E012-R16, 24 rue Lhomond, 4pm30).

We hope to see you on May 4 at 4pm30 for the first conference of the series by James Mayer from Yale University.

From Marc Fontecave, Gilles Gasser, Clotilde Policar and Raphaël Rodriguez

 

A series of conferences in bio-inorganic chemistry

presented by M. Fontecave (CdF), G. Gasser (Chimie Paris-Tech), Clotilde Policar (ENS) and Raphaël Rodriguez (Institut Curie).

PSL-BIC Program 2018

Room E012, salle des éléments, département de chimie de l’ENS, 24 rue Lhomond, 16h30

2018, May 4th

James M. Mayer

 

 

 

Charlotte Fitch Roberts Professor of Chemistry
Department of Chemistry, Yale University,

Invited professor P7

james.mayer @ yale.edu

 

Proton-Coupled Electron Transfer:
Fundamentals and Models for a Common Biochemical Mechanism

Proton-coupled electron transfer (PCET) reactions are ubiquitous, in both biological and non-biological contexts. This presentation will focus on simple model reactions that involve transfer of one electron and one proton, both hydrogen atom transfer reactions and reactions involving transfer of 1e and 1H+ a to (or from) cofactors that are spatially separated. A number of examples will be presented, including cases of O–H and C–H bond activations, and tyrosine oxidation across polyproline linkers.

2018, May, 11th

Dani Gibson

 

Institute for Drug Research, School of Pharmacy, The Hebrew University, Jerusalem, Israel

Invited professor ENS

dang @ ekmd.huji.ac.il

 

Multi-Action Platinum Anticancer Agents

To overcome the drawbacks of the clinically used Pt(II) drugs, we designed muti-action Pt(IV) prodrugs that can release inside the cancer cells two, three or four bioactive moieties that have different cellular targets.  This approach enhances the chances of killing the cancer cells. These compounds are very potent cytotoxic agents that were particularly effective against KRAS mutated cancers such as colon and pancreas.

2018, June 22nd

David Giedroc

 

 

 

 

Department of Chemistry, Indiana University, Bloomington, IN 47405-7102, USA; giedroc @ indiana.edu

 

 

 

Mechanisms of Zinc Metallostasis in Bacterial Pathogens

 

First-row late d-block transition metals from Mn to Zn play critical and distinct roles in many aspects of cellular metabolism. In bacterial pathogens, metalloregulation of transcription underscores physiological adaptation to host-mediated transition metal starvation and toxicity, required to maintain metal homeostasis (metallostasis). Recent efforts to understand allostery in Zn-regulated repressors using NMR spectroscopy and companion biophysical methods, will be presented primarily focused in the Zn efflux regulator from Staphylococcus aureus, CzrA, and a Zn uptake regulator adhesin-competence repressor (AdcR) from the Gram-positive respiratory pathogen, Streptococcus pneumoniae.

 

 

2018, September 3rd

Christian Hartinger

 

 

 

 

School of Chemical Sciences, University of Auckland
New Zealand; c.hartinger @ auckland.ac.nz

 

 

 

 

 

 

 

 

2018, October 5th

Christophe Copéret

 

 

 

 

 

 

 

Department of Chemistry and Applied Biosciences, , ETH Zurich, Switzerland ccoperet @ inorg.chem.ethz.ch

 

 

 

 

 

 

Molecular understanding and controlled functionalization of surfaces towards single-site catalysts and beyond

The rational design and development of functional materials, and catalysts in particular, requires a structure – property relationship approach, hence the need for strategies to control the generation of well-defined surface sites and for the development of characterization techniques with molecular-level precision.  Here, we first discuss the method to control and understand the chemistry at the surface of materials towards the development of so-called single-site catalysts and show how this approach can bring about information about industrial catalysts and be used to tailoring multifunctional catalysts.[1,2] In this context, we will show how Dynamic Nuclear Polarization Surface Enhanced NMR spectroscopy can provide insightful information about a broad range of materials, which are not available by other characterization techniques.[3] We will also how NMR chemical shifts can be used to predict the reactivity of molecules and how this molecular approach can be used to bridge the gap with other disciplines, such as Magnetic Resonance Imaging (MRI), data storage and microelectronics.

2018, November 9th

Joëlle Vinh

 

 

 

 

ESPCI, PSL University

joelle.vinh @ espci.fr

 

Mass Spectrometry as an Analytical Tool for Metal Complexes in Biological Samples

 

 

 

 

2018, November 21st

Hongjie Dai

 

 

 

 

Department of Chemistry, Indiana University, Bloomington, IN 47405-7102, USA

hdai1 @ stanford.edu

 

 

 

 

Carbon Based Nanosciences

This talk will review our work on nanosciences based on carbon. I will first briefly review our earlier work of carbon nanomaterials including carbon nanotubes and graphene nanoribbons, and then focus on fluorescence biological imaging in the newly opened 1000-1700 nm NIR-II window to benefit from greatly suppressed photon scattering at long wavelengths.  We show that NIR-II imaging is novel with up to millimeters tissue depth capable of sub-10 micron spatial resolution, using a wide range of fluorescent agents developed in our lab including carbon nanotubes, quantum dots, rare-earth nanoparticles, donor-acceptor conjugated polymers and small organic molecules.  The second part of the talk will focus on our work on advancing new types of electrocatalysts for renewable energy applications and the development of novel batteries. I will talk about the development of electrocatalysts for water splitting with high energy efficiency and lifetimes. I will also present our recent work on the development of rechargeable Al ion battery utilizing some of the most abundant materials on earth including graphite, aluminum and urea. The latest results on operando in situ X ray diffraction of anion-graphite intercalation will be presented.

2018, December 7th

Paul Dyson

 

 

Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland

paul.dyson @ epfl.ch

The Development of Organometallic Anticancer Drugs that Operate via Epigenetic Mechanisms

Following an introduction to the role of metal compounds in the treatment of cancer the seminar will focus on our own research on ruthenium-based organometallic (RAPTA) compounds that are active against chemoresistant and invasive tumours. We show that organometallic RAPTA-type drugs are able to overcome certain types of drug resistance mechanisms as they do not target DNA, but operate via epigenetic mechanisms. Furthermore, their mechanism of action leads to significant changes to the tumor microenvironment, which sensitizes tumors to other cytotoxic (DNA acting) drugs. The study of RAPTA-type compounds in combination with clinically approved compounds will therefore also be discussed.

 

30/04/18

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